As the NFL season kicks off this weekend, fantasy managers across the country are asking the same question: who should i start in Week 1? With several injury concerns, rookie debuts, and favorable matchups, lineup choices could make or break early season momentum.
The biggest headline surrounds San Francisco 49ers running back Christian McCaffrey, who was limited late in the week due to a minor calf issue. Reports indicate he is on track to play against the Seattle Seahawks. If he’s active, he remains a must-start option in every fantasy format. However, managers are encouraged to have backups ready should his workload be limited.
If McCaffrey sees fewer snaps, Brian Robinson offers strong value in point-per-reception (PPR) leagues. His ability to contribute in the passing game makes him a safe plug-in for Week 1. For standard scoring formats, Isaac Guerendo could be a sneaky option, particularly near the goal line where touchdown opportunities are likely.
At quarterback, fantasy eyes are on Drake Maye, the rookie leading the New England Patriots. Matched against a Raiders defense that struggled to contain passing attacks last season, Maye is ranked as a fringe QB1 for the week. Fantasy analysts suggest starting him over mid-tier options like Brock Purdy or Justin Herbert, especially in leagues where upside is critical.
Another name gaining steam is RJ Harvey, rookie running back for the Denver Broncos. Harvey impressed in preseason with his vision and explosiveness, building on a college career where he recorded over 1,500 rushing yards and 22 touchdowns last season. Facing a Tennessee Titans defense that had difficulty stopping the run in 2024, Harvey has the potential to deliver immediate fantasy value as an RB2 or flex starter.
Table of Contents
Key Week 1 Start Options
- Christian McCaffrey – Start if active; monitor workload closely.
- Brian Robinson – Safe PPR start if McCaffrey is limited.
- Isaac Guerendo – Consider in standard or touchdown-heavy leagues.
- Drake Maye – Rookie QB with top-12 upside this week.
- RJ Harvey – Strong flex option against a vulnerable run defense.
Who Should I Start: Making the Final Call
Week 1 decisions often come down to balancing star power with favorable matchups. Established names like McCaffrey demand trust when healthy, but emerging rookies such as Harvey and Maye offer breakout potential that can swing fantasy matchups. Managers should keep a close eye on injury updates through Sunday morning and be ready to pivot if any surprises occur.
Fantasy football is always a mix of preparation and adaptability. When you’re wondering who should i start, remember to weigh health status, projected game scripts, and scoring format. With the right mix of strategy and flexibility, Week 1 could set the tone for a winning season.
So, which way are you leaning with your lineup? Drop your toughest start-sit decision in the comments and join the conversation with other fantasy fans.